Indirect neuroprotection of Tecfidera (DMF) in RRMS and progressive patients
Multiple Sclerosis
Enrolment: 57 · Results not recorded
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Drug · Alkylates Keap1 to prevent interaction with Nrf2 (INHIBITOR, direct interaction, disease efficacy true)
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Multiple Sclerosis
Enrolment: 57 · Results not recorded
Relapsing-Remitting Multiple Sclerosis
Enrolment: 241 · Results not recorded
Multiple Sclerosis
Enrolment: 60 · Results not recorded
Relapsing-Remitting Multiple Sclerosis
Enrolment: 1736 · Results not recorded
Multiple Sclerosis, Relapsing-Remitting
Enrolment: 20 · Results not recorded
Psoriasis
Enrolment: 120 · Results not recorded
Adrenomyeloneuropathy Without Cerebral Involvement
Enrolment: 40 · Results not recorded
Rheumatoid Arthritis
Enrolment: 153 · Results not recorded
Relapsing-remitting Multiple Sclerosis
Enrolment: 267 · Results not recorded
Relapsing Forms of Multiple Sclerosis
Enrolment: 71 · Results not recorded
Healthy Volunteers
Enrolment: 80 · Results not recorded
Multiple Sclerosis
Enrolment: 8 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Acute binge ethanol exposure causing hepatic and pancreatic injury, in Nrf2-knockout and wildtype mice
Nrf2-knockout mice showed exaggerated hypoglycaemia and hypothermia, increased mortality and worse hepatic and pancreatic injury after binge ethanol. The clinically used NRF2 activator dimethyl fumarate protected against ethanol-induced hypoglycaemia and lethality
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: Corneal epithelial injury model in diabetic rats treated topically, together with an in vitro scratch wound assay in human retinal pigment epithelial (ARPE-19) cells cultured in medium containing normal (5 mM) or high (25 mM) glucose
Nrf2 nuclear translocation and heme oxygenase activity increased in ARPE-19 cells treated with 10 microM dimethylfumarate or carnosol irrespective of glucose concentration. High glucose reduced cellular and mitochondrial reactive oxygen species, reduced ATP production and mitochondrial function, an…
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Balloon catheter injury of the left common carotid artery (restenosis and neointimal hyperplasia model)
DMF dose-dependently reduced neointimal formation and Ki67 positivity after balloon injury and restored CD31 expression, consistent with improved re-endothelialisation. In vitro DMF arrested VSMCs at G0/G1 through p21 upregulation driven by Nrf2 (early) and p53 (late) and protected human aortic end…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.