Effects of incorporation of granule-lyophilised platelet-rich fibrin into polyvinyl alcohol hydrogel on wound healing.
MouseWoundn = n = 15 per group across 4 groups for the wound-healing stud…Topical application to the wound bed, covered with Tegaderm film1% G-L-PRF incorporated into 10% w/v PVA hydrogel; scaffold…Applied immediately after wound creation
Model: Two 6 mm diameter acute full-thickness excisional dorsal skin wounds created with a punch, stented with a donut-shaped silicone splint to prevent contraction
1% G-L-PRF/PVA accelerated wound closure at days 7 and 9 with full healing by day 11 versus day 13 for L-PRF and day 14 for blank and PVA groups, and increased granulation tissue, collagen deposition and maturity, VEGF expression and CD31-positive vessel density at days 7 and 9
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