THERAPY DOSSIER · th-4e4a37102fc0

Granule-lyophilised platelet-rich fibrin incorporated into polyvinyl alcohol hydrogel (1% G-L-PRF/PVA scaffold)

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01892514 ↗PHASE3completed

Core Decompression With DBM or Lyophilized Bone Chips Plus PRF and Concentrated Bone Marrow in Osteonecrosis of the Femoral Head

Osteonecrosis

Enrolment: 104 · Results not recorded

NCT06625528 ↗EARLY_PHASE1active not recruiting

Efficacy of Lyophilized Platelet-Rich Fibrin in Treatment of Periodontal Intra-Bony Defects

Periodontal Intra-bony Defects

Enrolment: 36 · Results not recorded

NCT07121348 ↗NAactive not recruiting

Effect of Different NanoScaffolds (platelet rich fibrin) on Pulp Regeneration in Non-Vital Immature Permanent Teeth

Necrotic Immature Permanent Incisors

Enrolment: 40 · Results not recorded

NCT07092488 ↗NAcompleted

Application of Platelet-Rich Fibrin in Revascularisation of Immature Permanent Teeth

Necrotic Immature Permanent Teeth

Enrolment: 28 · Results not recorded

NCT07022860 ↗NAcompleted

Radiographic Assessment of Platelet-Rich Fibrin on Socket Preservation

Socket Preservation

Enrolment: 12 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30232343 ↗2018Reported benefit

Effects of incorporation of granule-lyophilised platelet-rich fibrin into polyvinyl alcohol hydrogel on wound healing.

MouseWoundn = n = 15 per group across 4 groups for the wound-healing stud…Topical application to the wound bed, covered with Tegaderm film1% G-L-PRF incorporated into 10% w/v PVA hydrogel; scaffold…Applied immediately after wound creation

Model: Two 6 mm diameter acute full-thickness excisional dorsal skin wounds created with a punch, stented with a donut-shaped silicone splint to prevent contraction

1% G-L-PRF/PVA accelerated wound closure at days 7 and 9 with full healing by day 11 versus day 13 for L-PRF and day 14 for blank and PVA groups, and increased granulation tissue, collagen deposition and maturity, VEGF expression and CD31-positive vessel density at days 7 and 9

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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