IL-33 modulates inflammatory brain injury but exacerbates systemic immunosuppression following ischemic stroke.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/6 per MeSH indexing; knockout mice also usedMale
Model: Focal ischaemic stroke
IL-33 reduced infarct size, microglial activation and cytotoxic T cell infiltration and increased IL-10-expressing regulatory T cells, but exacerbated post-stroke lung bacterial infection with greater functional deficits and mortality at 24 hours; supplementary gentamicin and ampicillin mitigated t…
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