Biologic
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Dextran sodium sulfate-induced acute colitis
Exogenous IL-33 accelerated epithelial restitution and repair and reduced inflammation during recovery from acute colitis via miR-320.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Focal ischaemic stroke
IL-33 reduced infarct size, microglial activation and cytotoxic T cell infiltration and increased IL-10-expressing regulatory T cells, but exacerbated post-stroke lung bacterial infection with greater functional deficits and mortality at 24 hours; supplementary gentamicin and ampicillin mitigated t…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Single acute ozone exposure (1 ppm for 1 h) causing lung epithelial barrier injury and neutrophilic inflammation
Administration of recombinant mouse IL-33 reduced neutrophil recruitment in Il33-deficient mice, and loss of IL-33 or ST2 worsened epithelial injury and myeloid inflammation, indicating IL-33/ST2 signalling protects the epithelial barrier after ozone exposure.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
