Complement depletion with cobra venom factor alleviates acute hepatic injury induced by ischemia-reperfusion.
Model: Acute hepatic injury induced by ischaemia-reperfusion: open mid-diaphyseal transverse fracture of the left femur to simulate trauma, followed by haemorrhage (2.5 ml/100 g) maintaining mean arterial pressure at 30 +/- 5 mmHg for 90 min, then 20 min resuscitation with Ringer lactate at twice the volume of blood loss
High-dose and low-dose CVF pretreatment significantly prolonged survival versus ischaemia-reperfusion alone (P<0.01), with no difference between doses. Low-dose pretreatment reduced ALT and AST at 3, 6 and 24 h, attenuated histological damage, depleted CH50 and C5b-9 within 24 h, lowered C5b-9 depo…
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