Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Ischaemia-reperfusion
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
RatIschaemia-reperfusionHepaticSprague DawleyMale and female in 1:1 ration = 170 rats in total; 10 per group across five groups for surv…High dose 100 microg/kg and low dose 50 microg/kg, dissolve…CVF1 and CVF2 given 24 h before surgery as pretreatment; CVF3 given on day 2 af…
Model: Acute hepatic injury induced by ischaemia-reperfusion: open mid-diaphyseal transverse fracture of the left femur to simulate trauma, followed by haemorrhage (2.5 ml/100 g) maintaining mean arterial pressure at 30 +/- 5 mmHg for 90 min, then 20 min resuscitation with Ringer lactate at twice the volume of blood loss
High-dose and low-dose CVF pretreatment significantly prolonged survival versus ischaemia-reperfusion alone (P<0.01), with no difference between doses. Low-dose pretreatment reduced ALT and AST at 3, 6 and 24 h, attenuated histological damage, depleted CH50 and C5b-9 within 24 h, lowered C5b-9 depo…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
RatIschaemia-reperfusionIntestinal / mesentericSprague-Dawleymaleintravenous via tail vein24 h before the operation (pre-treatment)
Model: Intestinal ischaemia-reperfusion by superior mesenteric artery clamping for 60 min followed by 4 h reperfusion, causing remote acute lung injury
Cobra venom factor pre-treatment significantly attenuated lung histological injury, oedema and permeability, and reduced pulmonary malondialdehyde, myeloperoxidase, ICAM-1 and IL-8. Intestinal damage and raised plasma diamine oxidase were also alleviated.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
