Protective effect of berberine on aconite-induced myocardial injury and the associated mechanisms.
MixedChemical/toxinSprague Dawley rats; guinea pig strain not statedMalen = n=40 rats (4 groups) for the Chuan-wu myocardial injury stu…Intragastric for in vivo studies; bath perfusion for isolated papillary muscle8 mg/kg/day and 16 mg/kg/day in vivoPretreatment. Berberine started 3 days before Chuan-wu; in the aconitine arrhyt…
Model: Chuan-wu (Aconitum) 0.08 mg/kg intragastrically once daily for 3 days to induce acute myocardial injury and arrhythmia; intravenous aconitine infusion (10 microg/ml at 0.08 ml/min via femoral vein) to induce arrhythmia; and isolated guinea pig papillary muscle perfused with aconitine
Berberine at 8 and 16 mg/kg reversed Chuan-wu-induced ECG changes, reduced serum CK, CK-MB and LDH, and attenuated venous congestion and inflammatory infiltration, with 16 mg/kg most effective. Mortality was 3 of 10 in the Chuan-wu group, 1 of 10 at 8 mg/kg and 0 of 10 at 16 mg/kg. Berberine signif…
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