Nutraceutical
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
PreDiabetes · Abdominal Obesity · Hypertension · Dyslipidemias · Atherosclerotic Cardiovascular Disease
Enrolment: 2024 · Results not recorded
Dyspepsia · Chronic Gastritis · Gastric Cancer · Helicobacter Pylori Infection
Enrolment: 524 · Results not recorded
Cardiovascular Risk Factor
Enrolment: 84 · Results not recorded
Colorectal Adenomas
Enrolment: 1000 · Results not recorded
Schizophrenia · Schizophrenia Spectrum and Other Psychotic Disorders · Metabolic Syndrome x
Enrolment: 113 · Results not recorded
Chronic Endometritis
Enrolment: 206 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Chuan-wu (Aconitum) 0.08 mg/kg intragastrically once daily for 3 days to induce acute myocardial injury and arrhythmia; intravenous aconitine infusion (10 microg/ml at 0.08 ml/min via femoral vein) to induce arrhythmia; and isolated guinea pig papillary muscle perfused with aconitine
Berberine at 8 and 16 mg/kg reversed Chuan-wu-induced ECG changes, reduced serum CK, CK-MB and LDH, and attenuated venous congestion and inflammatory infiltration, with 16 mg/kg most effective. Mortality was 3 of 10 in the Chuan-wu group, 1 of 10 at 8 mg/kg and 0 of 10 at 16 mg/kg. Berberine signif…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Severe acute necrotising pancreatitis induced by a choline-deficient ethionine-supplemented (CDE) diet fed for 3 days, with associated lung injury
Berberine significantly reduced histological damage to pancreas and lung, lowered serum amylase and lipase, myeloperoxidase activity, cytokine production and mortality, and inhibited activation of NF-kappa B, JNK and p38 in the pancreas.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Acute heavy alcohol exposure by single oral gavage of 60% (v/v) alcohol at 15 ml/kg (approximately 7.103 g/kg), causing gastric and small intestinal mucosal injury; parallel in vitro alcohol exposure of Caco2 cells at 348 mmol/L
Berberine dose dependently prevented alcohol-induced congestion, oedema and necrosis of the duodenal mucosa (highest dose 300 mg/kg most effective, Kruskal-Wallis chi-squared 24.07, p = 7.735e-05 for injury score), lowered blood alcohol concentration even at lower doses, raised plasma ADH activity…
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.
