Integrative analysis of differentially expressed genes and miRNAs predicts complex T3-mediated protective circuits in a rat model of cardiac ischemia reperfusion.
RatIschaemia-reperfusionCardiacWistarMalen = n=5 per group (Sham, IR, IRT3) for functional, array and qR…Subcutaneous constant infusion via Alzet model 2ML4 miniosmotic pump3 microg/kg/day (a higher dose of 6 microg/kg/day was used…Started 24 h after ischaemia-reperfusion
Model: Myocardial ischaemia-reperfusion by snare occlusion of the left anterior descending coronary artery for 30 min followed by unrestrained reperfusion; only rats showing greater than 50 percent reduction of basal serum free T3 at 24 h were randomised to treatment
T3 replacement restored free T3 to sham levels without altering body weight, heart rate, respiration rate or body temperature, and better preserved LV end systolic diameter, ejection fraction and fractional shortening at 3 days. It reverted 87 dysregulated genes and 11 miRNAs, normalised Tp53 and S…
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