THERAPY DOSSIER · th-f677af0f1dd8

Triiodothyronine (T3) and thyroxine (T4)

Hormone · Thyroid hormone receptor agonist (AGONIST); direct interaction, disease efficacy true

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Evidence & regulatory context

Mechanism: Thyroid hormone receptor agonist (AGONIST); direct interaction, disease efficacy true
Target: CHEMBL2111462 (thyroid hormone receptor)
Injury models: Spinal cord injury · Ischaemia-reperfusion
Reported indication: Not recorded
First approval: 1956
Development stage: Not recorded
ChEMBL record: CHEMBL1544 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Liothyronine; L-triiodothyronine; T3; Cytomel; Triostat; Thybon
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03627611 ↗PHASE2completed

A Randomized Crossover Study, Examining Differential Effects of Levothyroxine and Liothyronine

Hypothyroidism · Biomarkers · Endocrine System Diseases

Enrolment: 69 · Results not recorded

Preclinical evidence 3

3 studies reported at therapy level; 3 evidence entries itemised.

PMID 6827328 ↗1983No effect reported

Effect of triiodo-L-thyronine on axonal regeneration in the rat spinal cord after acute compression injury.

RatSpinal cord injuryCompressionFemalen = 56 rats total, 28 in the T3 treatment group5 micrograms/kg dailyAfter injury, daily for 4 weeks

Model: Acute spinal cord compression injury at T-7

T3 did not improve clinical recovery, inclined-plane performance or pyramidal tract axon counts compared with controls, and did not affect the roughly 50 per cent retrograde axonal loss seen between 4 and 12 weeks in both groups.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.82. Machine-extracted fields require source verification.

PMID 7420154 ↗1980Reported benefit

The effect of exogenous thyroid hormones on functional recovery of the rat after acute spinal cord compression injury.

RatSpinal cord injuryCompressionFemaleStarted after injury

Model: Acute spinal cord compression injury

T3 treated rats showed significantly improved recovery at 12 and 16 weeks and T4 treated rats at 12 weeks, compared with untreated controls.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

PMID 30218079 ↗2018Reported benefit

Integrative analysis of differentially expressed genes and miRNAs predicts complex T3-mediated protective circuits in a rat model of cardiac ischemia reperfusion.

RatIschaemia-reperfusionCardiacWistarMalen = n=5 per group (Sham, IR, IRT3) for functional, array and qR…Subcutaneous constant infusion via Alzet model 2ML4 miniosmotic pump3 microg/kg/day (a higher dose of 6 microg/kg/day was used…Started 24 h after ischaemia-reperfusion

Model: Myocardial ischaemia-reperfusion by snare occlusion of the left anterior descending coronary artery for 30 min followed by unrestrained reperfusion; only rats showing greater than 50 percent reduction of basal serum free T3 at 24 h were randomised to treatment

T3 replacement restored free T3 to sham levels without altering body weight, heart rate, respiration rate or body temperature, and better preserved LV end systolic diameter, ejection fraction and fractional shortening at 3 days. It reverted 87 dysregulated genes and 11 miRNAs, normalised Tp53 and S…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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