Blood purification by nonselective hemoadsorption prevents death after traumatic brain injury and hemorrhagic shock in rats.
RatTBIControlled cortical impactSprague DawleyMaleExtracorporeal blood circulation through a treatment cartridgeAfter combined injury, following instrumentation with the extracorporeal circuit
Model: Controlled cortical impact traumatic brain injury combined with pressure-controlled haemorrhagic shock
Survival rose from 47 per cent in sham-treated rats to 86 per cent in haemoadsorption-treated rats, with altered circulating mediator concentrations during and after treatment and no treatment-related histological changes.
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