Post-stroke DHA Treatment Protects Against Acute Ischemic Brain Injury by Skewing Macrophage Polarity Toward the M2 Phenotype.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/6Male and femaleIntraperitoneal injection10 mg/kgImmediately after reperfusion
Model: Transient middle cerebral artery occlusion for 1 hour followed by reperfusion
Docosahexaenoic acid given after stroke reduced infarct volume and neurological deficits at 3 days, inhibited immune cell infiltration, promoted M2 macrophage polarisation centrally and in the circulation, and lowered blood pro-inflammatory factors. Macrophage depletion abolished the neuroprotectio…
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