Tissue plasminogen activator promotes white matter integrity and functional recovery in a murine model of traumatic brain injury.
MouseTBIUnspecifiedC57BL/6, including tPA-knockout miceMaleIntranasal
Model: Traumatic brain injury (contusion) in mice, with comparison of tPA-knockout and wild-type animals
Absence of endogenous tPA worsened white matter and neurological recovery up to 35 days after injury. Intranasal replenishment of recombinant tPA in knockout mice improved neurological function, white matter structural and functional integrity, and compensatory corticofugal sprouting, without incre…
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