Penumbral Based Novel Thrombolytic Therapy in Acute Ischemic Stroke
Cerebral Infarction · Brain Ischemia · Stroke
Enrolment: 20 · Results not recorded
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Biologic · is TPA, cleaves plasminogen to plasmin
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Cerebral Infarction · Brain Ischemia · Stroke
Enrolment: 20 · Results not recorded
Acute Ischemic Stroke
Enrolment: 225 · Results not recorded
Unspecified Adult Solid Tumor
Enrolment not recorded · Results not recorded
Ischemic Stroke
Enrolment: 65 · Results not recorded
Pulmonary Embolism
Enrolment: 9 · Results not recorded
Stroke
Enrolment: 76 · Results not recorded
5 studies reported at therapy level; 5 evidence entries itemised.
Model: cerebral ischaemia (stroke)
tPA protected oligodendrocytes and rescued white matter from ischaemic lesions independently of its proteolytic activity.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Traumatic brain injury (contusion) in mice, with comparison of tPA-knockout and wild-type animals
Absence of endogenous tPA worsened white matter and neurological recovery up to 35 days after injury. Intranasal replenishment of recombinant tPA in knockout mice improved neurological function, white matter structural and functional integrity, and compensatory corticofugal sprouting, without incre…
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Controlled cortical impact traumatic brain injury
Subacute intranasal tPA improved cognitive and sensorimotor recovery, lowered the cortical stimulation threshold, enhanced dentate gyrus neurogenesis and corticospinal axonal sprouting, and raised mature brain-derived neurotrophic factor levels.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Transient hypoxia-ischaemia: reversible ligation of the right common carotid artery with inhalation of 7.5% oxygen for 30 min, producing endogenous thrombosis and infarction
tPA at 0.5 h reduced mortality from 23.8% to 8.3% and infarct volume from 32.5% to 15.5%, and adding edaravone further reduced infarct to 6.4% (p=0.017) with 75% versus 40% 7-day survival. The benefit was lost with delay, and at 4 h mortality (26.6%) and infarct volume (30.5%) exceeded tPA alone.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
Model: Compression-induced spinal cord injury
Administration of tPA or its downstream effector ADAMTS-4 restored tPA-dependent activity lost after injury, reduced spinal cord chondroitin sulfate proteoglycan content, improved axonal regeneration and sprouting and produced long-term functional recovery.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.