Targeted Temperature Management: Peltier's Element-Based Focal Brain Cooling Protects Penumbra Neurons from Progressive Damage in Experimental Cerebral Ischemia.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMaleFocal cooling applied to the skull/brain surface in free-moving ratsTiming of cooling was varied experimentally across the acute phase, reperfusion…
Model: Transient and permanent middle cerebral artery occlusion
The device produced rapid and accurate cerebral hypothermia without altering core temperature and reduced acute ischaemic neuronal death, reperfusion injury, progressive penumbral damage and oedema formation.
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