effects of allogeneic mesenchymal stem cells in a rat model of acute ischemic kidney injury.
RatIschaemia-reperfusionRenalWistarMalen = 5 animals per group across 7 groups; a separate group of 40…Intra-aortic (suprarenal aorta) or intraparenchymal (corticomedullary zone) injectionApproximately 2 x 10^6 MSC per animal, given as approximate…Immediately after reflow (reperfusion)
Model: Bilateral renal pedicle clamping for 40 min (renal ischaemia-reperfusion induced acute kidney injury)
MSC treatment by either route markedly reduced renal dysfunction at 24 h, with serum creatinine 1.05 mg/dl (intra-aortic) and 1.00 mg/dl (intraparenchymal) versus 3.41 and 3.00 mg/dl in untreated ischaemic rats, BUN 58.9 and 57.2 versus 86.8 and 83.5 mg/dl, and GFR 0.31 versus 0.15 to 0.16 ml/min/1…
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