Phase I/II Study Evaluating Allogeneic Mesenchymal Stromal Cells in Adults With Recessive Dystrophic Epidermolysis Bullosa
Recessive Dystrophic Epidermolysis Bullosa
Enrolment: 10 · Results not recorded
Loading the evidence…
Biologic
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Recessive Dystrophic Epidermolysis Bullosa
Enrolment: 10 · Results not recorded
Myocardial Infarction
Enrolment: 20 · Results not recorded
Multiple Sclerosis, Relapsing-Remitting
Enrolment: 69 · Results not recorded
Inflammatory Bowel Diseases
Enrolment: 1 · Results not recorded
COVID-19 · Sars-CoV2
Enrolment: 10 · Results not recorded
Dilated Cardiomyopathy
Enrolment: 36 · Results not recorded
Leg Length Inequality
Enrolment: 6 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Bilateral renal pedicle clamping for 40 min (renal ischaemia-reperfusion induced acute kidney injury)
MSC treatment by either route markedly reduced renal dysfunction at 24 h, with serum creatinine 1.05 mg/dl (intra-aortic) and 1.00 mg/dl (intraparenchymal) versus 3.41 and 3.00 mg/dl in untreated ischaemic rats, BUN 58.9 and 57.2 versus 86.8 and 83.5 mg/dl, and GFR 0.31 versus 0.15 to 0.16 ml/min/1…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.
Model: Spinal cord transection model and, in a parallel study, acute contusive and compressive spinal cord injury
Grafted mesenchymal stem cells survived up to eight weeks and formed a perineurium-like sheath that enwrapped host myelin and axons, secreted trophic factors and superoxide dismutase-3 and preserved many intact regenerating axons at the injury site.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.