Metformin relieves acute respiratory distress syndrome by reducing miR-138 expression.
MouseEndotoxin/LPSBALB/cMaleGiven in advance of lipopolysaccharide challenge (pretreatment)
Model: Lipopolysaccharide induced acute respiratory distress syndrome
Metformin partially reversed pulmonary oedema, vascular exudation and neutrophil accumulation, reduced lipopolysaccharide-induced death and lowered inflammatory cytokines. In NR8383 alveolar macrophages it raised SIRT1 and lowered phosphorylated p38, ERK and NF-kB, with miR-138-5p confirmed to targ…
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