Increases in Microvascular Perfusion and Tissue Oxygenation via Vasodilatation After Anodal Transcranial Direct Current Stimulation in the Healthy and Traumatized Mouse Brain.
MouseTBIControlled cortical impactn = Four groups of 10 mice each (traumatic brain injury and sha…Transcranial, anode placed around the craniotomy with the counter electrode on the thorax0.1 mA for 15 min per sessionBeginning either 1 week or 3 weeks after traumatic brain injury
Model: Controlled cortical impact using a 3 mm flat-tip impounder at 5 m/s velocity and 2.0 mm depth from the cortical surface
Anodal tDCS increased regional cortical cerebral blood flow bilaterally in both injured and sham animals, dilated arterioles, raised capillary flow velocity and improved tissue oxygenation. Repetitive stimulation improved motor coordination, learning and memory, and spatial working memory. Recovery…
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