Intracolonic WR 2721 protection of the rat colon from acute radiation injury.
RatRadiationmaleIntracolonic instillationAt least 15 mg per animal was required for protectionAdministered before irradiation, with an optimal mucosal contact time of 30 to…
Model: Acute radiation injury of the colon following irradiation
Intracolonic WR 2721 produced a radioprotective effect with a dose modifying factor of 1.8 relative to controls, with no systemic absorption detected, supporting a rationale for clinical trial.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.