Schwann Cell Transplantation Subdues the Pro-Inflammatory Innate Immune Cell Response after Spinal Cord Injury.
RatSpinal cord injuryContusionFischerFemalen = 20 adult female Fischer rats in total; 5 animals per group…Intraspinal transplantation into the lesion site1 week after contusive spinal cord injury
Model: Contusive spinal cord injury at thoracic level T8 using a MASCIS impactor
Schwann cell transplantation reduced numbers of CD11b, CD68 and Iba1 positive immune cells at the lesion implant site, particularly iNOS positive pro-inflammatory cells, and increased CD68 positive cells of an intermediate Arg1 and iNOS double positive phenotype. Anti-inflammatory CD68/Arg1 positiv…
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