THERAPY DOSSIER · th-32ebd2de3023

Schwann cells (purified from sciatic nerves of adult female Fischer rats; EGFP-labelled cells used for immunohistology)

Biologic · Purified Schwann cells; cell therapy (clinically translated as autologous human Schwann cells).

Evidence & regulatory context

Mechanism: Purified Schwann cells; cell therapy (clinically translated as autologous human Schwann cells).
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02354625 ↗Injury indicationPHASE1completed

Safety of Autologous Human Schwann Cells in Chronic Spinal Cord Injury Receiving Rehabilitation

Spinal Cord Injury

Enrolment: 8 · Results not recorded

NCT01739023 ↗Injury indicationPHASE1completed

Safety of Autologous Human Schwann Cells in Subacute Spinal Cord Injury

Spinal Cord Injury

Enrolment: 9 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30154346 ↗2018Reported benefit

Schwann Cell Transplantation Subdues the Pro-Inflammatory Innate Immune Cell Response after Spinal Cord Injury.

RatSpinal cord injuryContusionFischerFemalen = 20 adult female Fischer rats in total; 5 animals per group…Intraspinal transplantation into the lesion site1 week after contusive spinal cord injury

Model: Contusive spinal cord injury at thoracic level T8 using a MASCIS impactor

Schwann cell transplantation reduced numbers of CD11b, CD68 and Iba1 positive immune cells at the lesion implant site, particularly iNOS positive pro-inflammatory cells, and increased CD68 positive cells of an intermediate Arg1 and iNOS double positive phenotype. Anti-inflammatory CD68/Arg1 positiv…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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