Acute effects of GM1 ganglioside: reduction in both behavioral asymmetry and loss of Na+, K+-ATPase after nigrostriatal transection.
RatTBIUnspecifiedmaleIntraperitonealFirst injection within 2 h after surgery for maximal effect; comparison groups…
Model: Partial unilateral surgical transection of the nigrostriatal pathway
GM1 given within 2 h of hemitransection reduced amphetamine-induced rotational asymmetry at 48 h and limited the loss of striatal membrane Na+,K+-ATPase activity to 10 per cent versus 38 per cent in controls. Injection 4 to 12 h after surgery, or pretreatment alone, had no significant effect on rot…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.