THERAPY DOSSIER · th-6208d904712c

GM1 ganglioside

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07519044 ↗PHASE4recruiting

Adjunctive GM1 to Mechanical Thrombectomy for Acute Anterior Circulation Large Vessel Occlusion

Stroke · Acute Ischemic Stroke

Enrolment: 868 · Results not recorded

NCT05239663 ↗PHASE3terminated

Ganglioside-Monosialic Acid in Post-chemotherapy Cognitive Impairment in Breast Cancer

Chemotherapy-Related Cognitive Impairment · Breast Cancer

Enrolment: 76 · Results not recorded

NCT06742216 ↗PHASE3completed

Efficacy and Safety of Monosialoganglioside in the Treatment of Acute Ischemic Stroke

Acute Ischemic Stroke

Enrolment: 1232 · Results not recorded

NCT06431971 ↗PHASE2unknown

Short-term Efficacy of Talineuren (GM1-based) and Placebo in Parkinson Disease

Parkinson Disease

Enrolment: 40 · Results not recorded

NCT04976127 ↗PHASE1terminated

Safety Evaluation of Intravenous Talineuren (GM1-based) in Parkinson's Disease

Parkinson Disease

Enrolment: 22 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 3015350 ↗1986Reported benefit

Acute effects of GM1 ganglioside: reduction in both behavioral asymmetry and loss of Na+, K+-ATPase after nigrostriatal transection.

RatTBIUnspecifiedmaleIntraperitonealFirst injection within 2 h after surgery for maximal effect; comparison groups…

Model: Partial unilateral surgical transection of the nigrostriatal pathway

GM1 given within 2 h of hemitransection reduced amphetamine-induced rotational asymmetry at 48 h and limited the loss of striatal membrane Na+,K+-ATPase activity to 10 per cent versus 38 per cent in controls. Injection 4 to 12 h after surgery, or pretreatment alone, had no significant effect on rot…

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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