Impact of Dental Pulp Stem Cells Overexpressing Hepatocyte Growth Factor after Cerebral Ischemia/Reperfusion in Rats.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMaleIntravenous transplantation through a catheterImmediately after transient middle cerebral artery occlusion (acute phase)
Model: Transient middle cerebral artery occlusion with reperfusion
Dental pulp stem cells overexpressing HGF reduced infarct volume compared with unmodified cells at 3 and 7 days. Both cell treatments improved motor function relative to vehicle at 7 days. HGF-overexpressing cells inhibited microglial activation and pro-inflammatory cytokine production, reduced neu…
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