THERAPY DOSSIER · th-c27b5523aeee

Dental pulp stem cells overexpressing hepatocyte growth factor (HGF)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30151417 ↗2018Reported benefit

Impact of Dental Pulp Stem Cells Overexpressing Hepatocyte Growth Factor after Cerebral Ischemia/Reperfusion in Rats.

RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMaleIntravenous transplantation through a catheterImmediately after transient middle cerebral artery occlusion (acute phase)

Model: Transient middle cerebral artery occlusion with reperfusion

Dental pulp stem cells overexpressing HGF reduced infarct volume compared with unmodified cells at 3 and 7 days. Both cell treatments improved motor function relative to vehicle at 7 days. HGF-overexpressing cells inhibited microglial activation and pro-inflammatory cytokine production, reduced neu…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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