Chloroquine Restores Ganglioside Homeostasis and Improves Pathological and Behavioral Outcomes Post-stroke in the Rat.
RatIschaemia-reperfusionCerebral (MCAO/stroke)WistarMaleIntraperitoneal45 mg/kg in vivo; 0.1 microM in primary cortical neurons in…Started 3 days before stroke induction
Model: Severe stroke injury (focal cerebral ischaemia)
Chloroquine prevented ganglioside dysregulation at 3 days and partially prevented complex ganglioside depletion at 21 days after stroke, protected primary cortical neurons against exogenous GM3 toxicity, prevented forelimb motor deficits, and was associated with decreased inflammation and neurodege…
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