Changes of Spinal Edema and Expression of Aquaporin 4 in Methylprednisolone-treated Rats with Spinal Cord Injury.
RatSpinal cord injuryUnspecifiedStated in the paper as Sprague-Dawley (SD) Wistar ratsMaleIntravenous, via the tail vein30 mg/kgAfter induction of acute spinal cord injury
Model: Acute spinal cord injury model
Methylprednisolone reduced spinal water content and aquaporin 4 expression relative to untreated injury, and improved histological appearance with clearer grey and white matter borders, reduced bleeding range, reduced karyopyknosis and less perivascular and neuronal oedema. The reported motor nerve…
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