Bromodomain and extraterminal domain-containing protein inhibition attenuates acute inflammation after spinal cord injury.
MouseSpinal cord injuryContusionC57BL/6FemaleIntraperitoneal30 mg/kgFirst dose 3 hours after spinal cord contusion
Model: Spinal cord contusion injury
JQ1 significantly decreased pro-inflammatory cytokine expression and leukocyte recruitment to the injury site by 3 days after contusion, and BET inhibition attenuated pro-inflammatory signalling in activated neural cell populations in vitro. However, the reduced inflammation did not translate into…
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