Evidence & regulatory context
- Mechanism
- BET bromodomain (BRD4/BRD2/BRD3) inhibitor. ChEMBL flags this molecule as a chemical probe (chemical_probe=1) with max_phase null and no entry in the ChEMBL mechanism table, so moa_list is empty; the BET-inhibitor assignment is from the primary literature and probe annotation, not from ChEMBL MoA records.
- Target
- Not recorded
- Injury models
- Spinal cord injury
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Preclinical/no trial
- ChEMBL max phase
- Not recorded
- Synonyms
- JQ1; (+)-JQ1; (S)-JQ1; JQ-1; 1268524-70-4
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
MouseSpinal cord injuryContusionC57BL/6Femalen = 72 female C57BL/6 mice in total; RT-qPCR n=24 at 4 h and n=…Intraperitoneal30 mg/kg diluted in 5% DMSO and 5% Tween-80 in salineFirst dose 2 h after the contusion
Model: Moderate contusion spinal cord injury at T11 after laminectomy using the Infinite Horizon impactor at 60 kDyn with tissue displacement of 450-600 um, under ketamine 90 mg/kg and xylazine 10 mg/kg anaesthesia; sham mice underwent the same surgery without contusion
JQ1 significantly reduced IL-6, IL-1beta and TNF-alpha mRNA at 4 h after injury, with IL-1beta still suppressed at 72 h, reduced CCL2 at 72 h and iNOS at 72 h, and increased IL-4 and IL-13 mRNA at 4 h and IL-10 at 72 h, changes corroborated at protein level for IL-10, IL-13 and IL-6. Long-term trea…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
MouseSpinal cord injuryContusionC57BL/6FemaleIntraperitoneal30 mg/kgFirst dose 3 hours after spinal cord contusion
Model: Spinal cord contusion injury
JQ1 significantly decreased pro-inflammatory cytokine expression and leukocyte recruitment to the injury site by 3 days after contusion, and BET inhibition attenuated pro-inflammatory signalling in activated neural cell populations in vitro. However, the reduced inflammation did not translate into…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
