Complement inhibition ameliorates blast-induced acute lung injury in rats: Potential role of complement in intracellular HMGB1-mediated inflammation.
RatOtherSprague-DawleyMalen = n = 8 per group at the 3 hour and 24 hour time points and n…Intravenous, bolus via tail veinStated as 500 micrograms/kg in the abstract and as 50 micro…30 minutes after blast overpressure exposure
Model: Blast overpressure exposure at 120 kPa from a compressed air-driven shock tube, causing acute lung injury
Blast overpressure increased systemic cytokine production and produced pulmonary oedema, inflammation, endothelial damage and haemorrhage. Early rhDAF treatment reduced these changes, lowered HMGB1, RAGE, NF-kappaB, C3a and C3aR expression, and reversed C3a-C3aR interaction and nuclear translocatio…
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