Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Ischaemia-reperfusion · Other
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
MouseIschaemia-reperfusionIntestinal / mesentericC57Bl/6MaleIntravenousAround ischaemia/reperfusion
Model: Mesenteric ischaemia/reperfusion
DAF attenuated CRP-enhanced intestinal and lung injury after mesenteric ischaemia/reperfusion by inhibiting complement and neutrophil infiltration.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
RatOtherSprague-DawleyMalen = n = 8 per group at the 3 hour and 24 hour time points and n…Intravenous, bolus via tail veinStated as 500 micrograms/kg in the abstract and as 50 micro…30 minutes after blast overpressure exposure
Model: Blast overpressure exposure at 120 kPa from a compressed air-driven shock tube, causing acute lung injury
Blast overpressure increased systemic cytokine production and produced pulmonary oedema, inflammation, endothelial damage and haemorrhage. Early rhDAF treatment reduced these changes, lowered HMGB1, RAGE, NF-kappaB, C3a and C3aR expression, and reversed C3a-C3aR interaction and nuclear translocatio…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
