Repression of the Glucocorticoid Receptor Aggravates Acute Ischemic Brain Injuries in Adult Mice.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)CD1Malen = 81 mice used in total (72 purchased, negative control n=35,…Intracerebroventricular injection into the left lateral ventricle100 pmol GR siRNA in a total volume of 4 microlitres48 h before middle cerebral artery occlusion
Model: Intraluminal middle cerebral artery occlusion for 50 min followed by reperfusion
Glucocorticoid receptor knockdown lowered GR but not MR protein, raised brain IL-6, IL-1 beta and TNF-alpha both at baseline and 12 h after occlusion, and reduced TrkB and mature BDNF. Infarction size increased (25.16% plus or minus 11.69% versus 15.96% plus or minus 6.85%), neurological score fell…
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