THERAPY DOSSIER · th-8491e7a67c57

Glucocorticoid receptor siRNA (knockdown)

Other

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30126083 ↗2018Reported harm

Repression of the Glucocorticoid Receptor Aggravates Acute Ischemic Brain Injuries in Adult Mice.

MouseIschaemia-reperfusionCerebral (MCAO/stroke)CD1Malen = 81 mice used in total (72 purchased, negative control n=35,…Intracerebroventricular injection into the left lateral ventricle100 pmol GR siRNA in a total volume of 4 microlitres48 h before middle cerebral artery occlusion

Model: Intraluminal middle cerebral artery occlusion for 50 min followed by reperfusion

Glucocorticoid receptor knockdown lowered GR but not MR protein, raised brain IL-6, IL-1 beta and TNF-alpha both at baseline and 12 h after occlusion, and reduced TrkB and mature BDNF. Infarction size increased (25.16% plus or minus 11.69% versus 15.96% plus or minus 6.85%), neurological score fell…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.

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