Astragaloside IV Attenuates Acetaminophen-Induced Liver Injuries in Mice by Activating the Nrf2 Signaling Pathway.
MouseChemical/toxinICR (specific pathogen-free)Malen = 40 mice, four groups of 10Oral20 and 40 mg/kg per dayPre-treatment for 7 consecutive days, with the final dose given 1 h before acet…
Model: Acetaminophen-induced acute liver injury, single oral dose of 400 mg/kg acetaminophen, animals sacrificed 4 h later
Astragaloside IV pre-treatment at 20 and 40 mg/kg significantly reduced serum alanine and aspartate aminotransferase, alleviated necrosis and inflammation on histology, restored hepatic glutathione and superoxide dismutase, lowered malondialdehyde, suppressed TNF-alpha, IL-1beta and IL-6, increased…
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