Effect of acute muscle contusion injury, with and without dietary fish oil, on adult and aged male rats: contractile and biochemical responses.
RatCrushLimb / muscle crushMalen = Adult n = 14, aged n = 12Dietary (oral)8 weeks of supplementation before contusion injury
Model: Acute contusion injury of the gastrocnemius muscle, assessed 48 h post-injury with uninjured muscles as controls
Injury reduced force production by about 40 per cent and sarcoplasmic reticulum calcium release by about 20 per cent and increased damage markers, without an effect of ageing. Fish oil did not reduce functional deficits but increased Myf5 and attenuated the injury-associated decline in DRP1.
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