THERAPY DOSSIER · th-ef0b7e97e11b

Dietary fish oil (omega-3)

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Crush
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 7

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04836052 ↗PHASE3unknown

Omega-3 Oil Use in COVID-19 Patients in Qatar

COVID-19

Enrolment: 372 · Results not recorded

NCT01745263 ↗PHASE3completed

Vitamin D3 - Omega3 - Home Exercise - Healthy Ageing and Longevity Trial (DO-HEALTH)

Healthy Ageing

Enrolment: 2157 · Results not recorded

NCT03167307 ↗PHASE3completed

Omega-3 Fatty Acids as First-line Treatment in Paediatric Depression

Depression

Enrolment: 257 · Results not recorded

NCT03395119 ↗PHASE1completed

Efficacy of Fish Oil or Olive Oil Supplementation on Health Effects of Ozone Exposure

Healthy

Enrolment: 44 · Results not recorded

NCT05145452 ↗NAterminated

n-3 Polyunsaturated Fatty Acids to Prevent and Treat Diabetic Neuropathy

Diabetic Neuropathies

Enrolment: 31 · Results not recorded

NCT06736925 ↗NArecruiting

Mechanistic Investigation of Omega-3 Fatty Acids Pretreatment Effects on Subconcussive Brain Injury

Subconcussive Head Impact

Enrolment: 208 · Results not recorded

NCT06665464 ↗NAcompleted

Bioavailability of Omega-3 Fatty Acids From Fish Oil Supplements

Nutrition

Enrolment: 12 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30103026 ↗2018Mixed findings

Effect of acute muscle contusion injury, with and without dietary fish oil, on adult and aged male rats: contractile and biochemical responses.

RatCrushLimb / muscle crushMalen = Adult n = 14, aged n = 12Dietary (oral)8 weeks of supplementation before contusion injury

Model: Acute contusion injury of the gastrocnemius muscle, assessed 48 h post-injury with uninjured muscles as controls

Injury reduced force production by about 40 per cent and sarcoplasmic reticulum calcium release by about 20 per cent and increased damage markers, without an effect of ageing. Fish oil did not reduce functional deficits but increased Myf5 and attenuated the injury-associated decline in DRP1.

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.

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