Dimethyl Sulfoxide Prevents Radiation-Induced Oral Mucositis Through Facilitating DNA Double-Strand Break Repair in Epithelial Stem Cells.
MouseRadiationC57BL/6J; CAL-27 tumour xenograft miceMaleIntraperitoneal injectionPretreatment before irradiation
Model: Acute radiation-induced oral mucositis produced by high single-dose and fractionated irradiation of the head and neck area
DMSO pretreatment protected the oral mucosa from severe acute radiation injury, limited weight loss and preserved proliferative lingual epithelial stem and progenitor cells, with efficacy superior to keratinocyte growth factor and amifostine and no significant effect on tumour weight in xenograft m…
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