Protective Effects of a Rho Kinase Inhibitor on Paraquat-Induced Acute Lung Injuries in Rats.
RatChemical/toxinWistarn = 240 rats totalIntraperitoneal10 and 30 mg/kg1 hour prior to paraquat administration
Model: Paraquat-induced acute lung injury, with parallel in vitro paraquat exposure of human pulmonary microvascular endothelial cells
Fasudil pretreatment reduced neutrophil influx, alveolar protein leak and inflammatory cytokines, lowered lung oedema, injury score and oxidative damage markers, raised superoxide dismutase activity and ZO-1 expression and shifted apoptotic gene expression, with greater effect at the higher dose.
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