Early Intracoronary Fasudil Hydrochloride on Myocardial Perfusion in Primary PCI of STEMI
ST Segment Elevation Myocardial Infarction
Enrolment: 600 · Results not recorded
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Drug · ROCK1/ROCK2 (Rho-associated protein kinase) inhibitor (ChEMBL mec_id 8778, INHIBITOR, direct interaction). Isoquinoline sulphonamide vasodilator; approved in Japan and China for cerebral vasospasm after subarachnoid haemorrhage but not FDA-approved, hence ChEMBL max_phase 3 with no first_approval year. ATC C04AX32.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
ST Segment Elevation Myocardial Infarction
Enrolment: 600 · Results not recorded
Diabetic Macular Edema
Enrolment: 74 · Results not recorded
Retinopathy of Prematurity
Enrolment: 184 · Results not recorded
Cardiovascular Diseases
Enrolment: 31 · Results not recorded
Ovarian Cancer
Enrolment: 20 · Results not recorded
Carotid Stenosis
Enrolment: 2 · Results not recorded
Dementia
Enrolment: 24 · Results not recorded
Amyotrophic Lateral Sclerosis
Enrolment: 120 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Paraquat-induced acute lung injury, with parallel in vitro paraquat exposure of human pulmonary microvascular endothelial cells
Fasudil pretreatment reduced neutrophil influx, alveolar protein leak and inflammatory cytokines, lowered lung oedema, injury score and oxidative damage markers, raised superoxide dismutase activity and ZO-1 expression and shifted apoptotic gene expression, with greater effect at the higher dose.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Acute ozone-induced lung injury (4 h, 1 ppm ozone or filtered air) superimposed on 3 weeks of continuous hypoxia (10.0% O2) induced pulmonary arterial hypertension, versus normoxia (20.9% O2)
Hypoxia raised right ventricular pressure and produced right ventricular hypertrophy. Ozone alone caused airway inflammation in normoxic mice, while combined hypoxia and ozone markedly increased lung weight, lung water, bronchoalveolar lavage cellularity and methacholine-induced airway resistance.…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.