Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models.
MouseIschaemia-reperfusionCardiacC57BL/6 including knockout strains; miniature swineMaleIntravenousAt the time of reperfusion in the ischaemia-reperfusion model; starting 6 h aft…
Model: Myocardial ischaemia-reperfusion injury and permanent left anterior descending artery ligation myocardial infarction
Pioglitazone nanoparticles attenuated ischaemia-reperfusion injury, reduced inflammatory monocyte recruitment, promoted M2 macrophage polarisation, attenuated cardiac remodelling and decreased mortality after myocardial infarction, with cardioprotection confirmed in a conscious porcine model. Free…
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