Antioxidant treatment after injury suppresses second hit immune priming.

Antioxidant treatment after injury suppresses second hit immune priming.

Model: Pulmonary contusion followed by a second hit of Streptococcus pneumoniae infection or bacterial lipopolysaccharide

Pulmonary contusion produced oxidants that S-nitrosylated and reduced SIRT1, priming the lung for an exaggerated second-hit response. Antioxidant treatment after injury preserved SIRT1 activity, reduced second-hit responses and improved lung function.

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