Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Other · Crush
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
MouseOtherC57BL/6MaleAfter injury
Model: Pulmonary contusion followed by a second hit of Streptococcus pneumoniae infection or bacterial lipopolysaccharide
Pulmonary contusion produced oxidants that S-nitrosylated and reduced SIRT1, priming the lung for an exaggerated second-hit response. Antioxidant treatment after injury preserved SIRT1 activity, reduced second-hit responses and improved lung function.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
MouseCrushLimb / muscle crush
Model: Rhabdomyolysis-induced acute kidney injury (crush syndrome model)
The study identifies macrophage extracellular traps promoted by heme-activated platelets as a mediator of rhabdomyolysis-induced acute kidney injury and reports a new therapeutic tool for prevention, but the abstract does not name the agent, dose or route.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.4. Machine-extracted fields require source verification.
