Progesterone decreases the extent of ovarian damage caused by cisplatin in an experimental rat model.
RatChemical/toxinFemalen = 40 rats in four groupsIntramuscular8 mg/kgPre-treatment given before cisplatin injection
Model: Cisplatin-induced ovarian damage; cisplatin 5 mg/kg per week intraperitoneally
Cisplatin caused ovarian damage with reduced anti-Muellerian hormone immunoreactivity and increased apoptosis. Progesterone co-administration significantly reduced the number of TUNEL-positive cells, indicating a protective effect on the ovary.
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