THERAPY DOSSIER · th-b678cd4d44fb

Progesterone

Hormone · Progesterone receptor agonist (AGONIST), direct interaction, disease efficacy true.

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This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: Progesterone receptor agonist (AGONIST), direct interaction, disease efficacy true.
Target: CHEMBL208
Injury models: TBI · Spinal cord injury · Other · Chemical/toxin
Reported indication: Not recorded
First approval: 1976
Development stage: Not recorded
ChEMBL record: CHEMBL103 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Prometrium; Crinone; Utrogestan; Endometrin; Cyclogest
Note: Not recorded

Clinical trials 7

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01940653 ↗PHASE4completed

Optimal Length of Progesterone Supplementation Before Frozen-Thawed Embryo Transfer

Progesterone Supplementation

Enrolment: 300 · Results not recorded

NCT02969590 ↗PHASE4completed

Regulation of Cervical Mucus Secretion (estrogen and progesterone replacement)

Fertility · Contraception

Enrolment: 5 · Results not recorded

NCT00029536 ↗PHASE3completed

Phase 3 Study of Progesterone vs Placebo Therapy

Epilepsy

Enrolment: 294 · Results not recorded

NCT01057511 ↗PHASE1/PHASE2completed

Progesterone Concentration in Serum and Endometrium After Vaginal and IM Progesterone

Postmenopausal Endometrium

Enrolment: 51 · Results not recorded

NCT04531943 ↗NAcompleted

Feminizing Hormone Therapy (estrogen +/- progesterone) and Rectal Mucosa Immune Environment

HIV Prevention

Enrolment: 285 · Results not recorded

NCT07642700 ↗NAnot yet recruiting

GnRH Agonist Pretreatment With Estrogen-Progesterone Endometrial Preparation

Chronic Endometritis

Enrolment: 150 · Results not recorded

NCT04312399 ↗NArecruiting

Hormone Replacement Trial Against Alzheimers' Disease

Postmenopausal Symptoms · Alzheimer Disease

Enrolment: 600 · Results not recorded

Preclinical evidence 19

8 studies reported at therapy level; 19 evidence entries itemised.

PMID 23088810 ↗2012Reported harm

Effect of hormone replacement therapy in matrix metalloproteinase expression and intimal hyperplasia development after vascular injury.

RatOtherSprague-DawleyFemaleSubcutaneous slow release pelletStarted 4 weeks after ovariectomy, 6 weeks before balloon angioplasty

Model: Balloon angioplasty injury of the left common carotid artery in ovariectomised aged rats

Hormone therapy raised intima to media ratio versus placebo without reaching significance and increased MMP-2 and MMP-9 without a compensatory rise in TIMP-2.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

PMID 23546895 ↗2013Reported benefit

Combined treatment with progesterone and magnesium sulfate positively affects traumatic brain injury in immature rats.

RatTBIUnspecifiedWistarIntraperitonealProgesterone 8 mg/kg; magnesium sulfate 150 mg/kgImmediately after induction of traumatic brain injury

Model: Contusion injury of the immature brain

Combined progesterone and magnesium sulfate reduced trauma-induced neuronal death and acute hippocampal and prefrontal apoptosis, raised brain VEGF above either drug alone, and improved the spatial memory deficits that appeared later in life.

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

PMID 21549006 ↗2011Mixed findings

Genomic profile of Toll-like receptor pathways in traumatically brain-injured mice: effect of exogenous progesterone.

MouseTBIControlled cortical impactC57BL/6JMaleintraperitoneal16 mg/kg1 and 6 h after surgery

Model: bilateral controlled cortical impact injury

Progesterone down-regulated three injury-induced target genes (Ccl2, IL-1b, Cxcl10) but did not inhibit TLRs or their adaptors after TBI.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

PMID 21704617 ↗2011Reported benefit

Progesterone attenuates astro- and microgliosis and enhances oligodendrocyte differentiation following spinal cord injury.

RatSpinal cord injuryUnspecifiedSprague-DawleyMaleAcute (3 days) or chronic (21 days) administration

Progesterone inhibited astrocyte and microglial activation and promoted oligodendrocyte differentiation and remyelination after spinal cord injury in rats.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

PMID 30066501 ↗2019Reported benefit

Progesterone decreases the extent of ovarian damage caused by cisplatin in an experimental rat model.

RatChemical/toxinFemalen = 40 rats in four groupsIntramuscular8 mg/kgPre-treatment given before cisplatin injection

Model: Cisplatin-induced ovarian damage; cisplatin 5 mg/kg per week intraperitoneally

Cisplatin caused ovarian damage with reduced anti-Muellerian hormone immunoreactivity and increased apoptosis. Progesterone co-administration significantly reduced the number of TUNEL-positive cells, indicating a protective effect on the ovary.

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

PMID 28062253 ↗2017Reported benefit

Spinal neuropeptide expression and neuropathic behavior in the acute and chronic phases after spinal cord injury: Effects of progesterone administration.

RatSpinal cord injuryHemisection / partialMaleSubcutaneousEarly treatment started after injury and sustained

Model: Spinal cord hemisection at the T13 level

Hemisection increased Y1R and Y2R and reduced GalR2 mRNA at 1 day, and increased galanin, NPY, GalR1 and Y1R at 28 days alongside established mechanical and cold allodynia. Early and sustained progesterone prevented Y1R upregulation acutely, normalised galanin, NPY, GalR1 and Y1R chronically, reduc…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.

PMID 27150077 ↗2016Reported benefit

Temporal changes in the expression of the translocator protein TSPO and the steroidogenic enzyme 5alpha-reductase in the dorsal spinal cord of animals with neuropathic pain: Effects of progesterone administration.

RatSpinal cord injuryUnspecifiedSprague-DawleyMaleInjection

Model: Spinal cord injury producing central chronic neuropathic pain, with assessment at 1, 14 and 28 days

Progesterone-treated injured rats did not develop allodynia and showed increased spinal TSPO, StAR and 5alpha-reductase I and II mRNA at 28 days after injury.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

PMID 25093611 ↗2014Reported benefit

Effects of progesterone vs. dexamethasone on brain oedema and inflammatory responses following experimental brain resection.

RatTBIUnspecifiedSprague DawleyMalen = 75 adult male rats randomised into five groupsProgesterone 10 mg/kg (low dose) or 20 mg/kg (high dose); d…

Model: Surgical brain injury induced by experimental brain resection

The model consistently increased brain water content and disrupted the blood-brain barrier. Progesterone reduced astrocyte and microglia responses and attenuated brain oedema with preservation of the blood-brain barrier, and was as effective as dexamethasone in reducing brain oedema and inflammatio…

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

PMID 18584320 ↗2009

Progesterone effects on neuronal ultrastructure and expression of microtubule-associated protein 2 (MAP2) in rats with acute spinal cord injury

RatSpinal cord injury

Extraction: mesh. Machine-extracted fields require source verification.

PMID 16797538 ↗2006

Tapered progesterone withdrawal promotes long-term recovery following brain trauma

RatTBI

Extraction: mesh. Machine-extracted fields require source verification.

PMID 16259981 ↗2006

Physiologic progesterone reduces mitochondrial dysfunction and hippocampal cell loss after traumatic brain injury in female rats

RatTBI

Extraction: mesh. Machine-extracted fields require source verification.

PMID 11939502 ↗2002

Cellular basis for progesterone neuroprotection in the injured spinal cord

RatSpinal cord injury

Extraction: mesh. Machine-extracted fields require source verification.

PMID missing2001

Effects of the duration of progesterone treatment on the resolution of cerebral edema induced by cortical contusions in rats

TBI

Extraction: not specified. Machine-extracted fields require source verification.

PMID 10543012 ↗1999

Progesterone is neuroprotective after acute experimental spinal cord trauma in rats

RatSpinal cord injury

Extraction: mesh. Machine-extracted fields require source verification.

PMID 19738320 ↗2009

Progesterone decreases cortical and sub-cortical edema in young and aged ovariectomized rats with brain injury

RatTBI

Extraction: mesh. Machine-extracted fields require source verification.

PMID 17892409 ↗2007

Progesterone improves acute recovery after traumatic brain injury in the aged rat

RatTBI

Extraction: mesh. Machine-extracted fields require source verification.

PMID 17826908 ↗2007

Neurosteroids reduce inflammation after TBI through CD55 induction

RatTBI

Extraction: mesh. Machine-extracted fields require source verification.

PMID 16870241 ↗2006

Slow-release and injected progesterone treatments enhance acute recovery after traumatic brain injury

RatTBI

Extraction: mesh. Machine-extracted fields require source verification.

PMID 16039652 ↗2005

Tapered progesterone withdrawal enhances behavioral and molecular recovery after traumatic brain injury

RatTBI

Extraction: mesh. Machine-extracted fields require source verification.

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