Osthole Protects against Acute Lung Injury by Suppressing NF-B-Dependent Inflammation.
MouseEndotoxin/LPSC57BL/6Malen = Seven mice per group in four groups for the acute lung inju…Intraperitoneal20 and 40 mg/kgPre-treatment, with the final dose 0.5 h before lipopolysaccharide challenge
Model: Lipopolysaccharide-induced acute lung injury and lethal endotoxaemia; lipopolysaccharide 20 mg/kg injected via the tail vein
Osthole inhibited the lipopolysaccharide-induced inflammatory response in peritoneal macrophages by blocking NF-kappaB nuclear translocation, prolonged survival of septic mice beyond 72 h at 20 and 40 mg/kg with less weight loss, and reduced lung tissue injury, leukocyte recruitment and cytokine pr…
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