Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Endotoxin/LPS · TBI
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
MouseEndotoxin/LPSC57BL/6Malen = Seven mice per group in four groups for the acute lung inju…Intraperitoneal20 and 40 mg/kgPre-treatment, with the final dose 0.5 h before lipopolysaccharide challenge
Model: Lipopolysaccharide-induced acute lung injury and lethal endotoxaemia; lipopolysaccharide 20 mg/kg injected via the tail vein
Osthole inhibited the lipopolysaccharide-induced inflammatory response in peritoneal macrophages by blocking NF-kappaB nuclear translocation, prolonged survival of septic mice beyond 72 h at 20 and 40 mg/kg with less weight loss, and reduced lung tissue injury, leukocyte recruitment and cytokine pr…
Extraction: extract · Supplied extraction confidence: 0.88. Machine-extracted fields require source verification.
MouseTBIPenetrating / ballisticC57BL/6
Model: Cortical stab wound mechanical brain injury
Osthole promoted endogenous neural stem cell proliferation, increased neuron numbers in the injured cortex and hippocampal DG and CA3 and improved learning and memory in the Morris water maze; these effects were abolished by the Notch inhibitor DAPT, indicating Notch pathway involvement.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
