Melatonin improves quality and longevity of chronic neural recording.
MouseTBIUnspecifiedC57BL/6JMalen = 20 mice total: control n=6, acute melatonin n=6, chronic me…Intraperitoneal30 mg/kg in 100 microlitres, dispersed in DMSO then made up…Started 3 days before implantation surgery and continued after implantation
Model: Chronic intracortical microelectrode implantation injury in visual cortex, 3 mm single-shank planar silicon probe (NeuroNexus A1x16-3MM-100-703-CM15), followed for 16 weeks
Chronic daily melatonin maintained significantly higher single-unit yield, signal-to-noise ratio and amplitude than saline across 16 weeks and outperformed acute dosing from week 4 onward, with about 49 per cent more neurons at 0 to 10 micrometres, 70 per cent fewer caspase-3 positive neurons at 10…
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