Pharmacological Characters of Oliceridine, a μ-Opioid Receptor G-Protein-Biased Ligand in Mice.
MouseFractureTibiaC57BL/6JMaleSubcutaneousFracture study: 2.5 mg/kg first dose then 5 mg/kg twice dai…Treatment started immediately after fracture and pinning surgery, first dose on…
Model: Right tibial fracture with intramedullary pinning using a 27-gauge stainless steel needle, with sham-operated controls; plus tail flick and von Frey assays in uninjured mice
Oliceridine was about four times more potent than morphine in the tail flick assay (ED50 1.31 mg/kg versus 5.26 mg/kg) and produced no analgesic tolerance, less opioid-induced hyperalgesia, better recovery of nociceptive sensitisation and gait after tibial fracture, and no rise in spinal TLR4 mRNA.…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.